Over the next decade, we will see a large influx of high-precision cosmic microwave background (CMB) and large-scale structure (LSS) data. We will not only have exquisite primary CMB data, but also excellent sensitivity to CMB secondaries and tracers of LSS. So far, CMB secondaries and LSS observations have mainly been employed to constrain astrophysical properties and the cosmological standard model. In this talk, I will discuss the impact that these observables may have on physics beyond the Standard Model as exemplified by dark matter-baryon interactions. I will focus on CMB lensing and galaxy clustering, including the effects of baryonic effects and gravitational nonlinearities, and present constraints on these interactions from galaxy clustering data of the Baryon Oscillation Spectroscopic Survey (BOSS) that are competitive with those from Planck.