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Using Nanopores to Watch Enzymes at Work

Jens Gundlach
Monday, October 28, 2019 - 4:00pm to 5:00pm
PAA 102

We have developed a high-resolution molecular sensor based on an ion current flowing through a protein nanopore. This sensor has enabled nanopore sequencing of DNA. Here, I will show how we have further adapted our technology to be a novel single-molecule tool called SPRNT (Single-molecule Picometer Resolution Nanopore Tweezers). SPRNT permits real-time observation of enzyme mechanics with spatio-temporal resolution far beyond that of optical tweezers. I will show why this research may matter to you.

Panopto link.

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